ABOUT PONICIDIN

TAK-243 preferentially certain to UBA1 above the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 diminished amounts of ubiquitylated proteins, greater markers of proteotoxic pressure and DNA problems anxiety. In vivo, TAK-243 lessened leukemic burden and qualified leukemic stem cells devoid of proof of